This study, which is proposed as a two-year program, develop a computerized cognitive diagnostic assessment and remedial instruction system based on the cognitive diagnostic model. The main contribution of this study is to use cognitive diagnostic model to automatically detect students’ learning weaknesses, prescribe customized remedial instructions accordingly, and reduce teachers’ workload with the assistance of technology to conduct assessment and remedial instruction. The objectives for the first year of this study are 1) to design cognitive diagnostic assessment for mathematics 2) to develop the non-parametric cognitive diagnostic assessment capable of error pattern diagnosis 3) to determine the effectiveness of the cognitive diagnostic mode with simulation studies and evidence, and for the second year 1) to develop the computerized cognitive diagnostic assessment and remedial instruction system based on the cognitive diagnostic model 2) to construct remedial instruction materials based on the cognitive diagnostic model 3) to evaluate the cognitive diagnostic assessment and remedial instruction system through field experiment. The results of the study include a fully developed cognitive diagnostic assessment for fraction problems that is capable of cognitive attribute diagnosis, and 593 student samples collected that translate to a reliability of 0.88 and validities based on the consistency measured between the assessment result and expert judgment on eight cognitive attributes, which all exceed 0.90. The simulations and evidence have shown that parametric cognitive diagnostic models have higher correctness rate of diagnosis, so parametric cognitive diagnostic model is adopted during the construction of the computerized cognitive diagnostic assessment and remedial instruction system. The field experiment, which has a sample of 83 students, then shows significant difference between experimental group and control group that score 84 and 80 respectively on average, and yet the effect size is not large which may results from the limited time for the remedial instruction where some students cannot finish all of the videos. But, in the end, most of the students agree that this mode of remedial instruction can help when learning mathematics.