The purpose of this study is to investigate the effect of reading strategy under single subject design using meta analysis. After searching and selecting the electronic database , totally 51 articles, which containing 171 subjects were included in the analysis. The results show that different reading strategy has median immediate effect (PND=74.72%,PEM=87.02%) and maintaining effect (PND=75.77,PEM=89.03) for Chinese reading comprehension。The moderator analysis show that multi-strategy is better than single strategy. The digital text is better than electronic text, illustrated text and paper text. Finally, direct teaching has better immediate and maintaining effect than other teaching approach.